Often overshadowed by terrorism, nuclear weapons, and cybercrime in the public imagination, pandemics may actually be the more existential threat to human civilization. And most experts agree: We’re woefully unprepared, and crucial funding for basic research, foreign aid, and preparedness is on the chopping block. What lessons have we learned from the Ebola crisis that can be applied to Zika and other threats, both natural and manmade in the months and years to come? What leadership and reforms are needed to make sure we’re as prepared as possible to confront the next epidemic?